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In a worst case-scenario, cells are incapable to degrade carcinogens or stress-induced toxic intermediates, thus increasing their susceptibility to undergo further steps toward cancer progression or event other diseases ( B (Val105) allele is often mentioned within the context of genetic polymorphisms, a GSTP1 variation which is characterized by an AG sequence transition in codon 105 of exon 5, leading to the exchange of isoleucine by valine, thus decreasing its catalytic activity associated with reduced cell detoxification ability (Saxena et al., 2012)
Soni R, Durgapal SD, Soman SS, Georrge JJ
Excessive acetyl-CoA production in the process of -oxidation inhibits the tricarboxylic acid (TCA) cycle, leading to mitochondria stress in hepatocytes [9, 10]
Symptoms of psycho-logical distress andsuicidal ideation among banana workers witha history of poisoning by organophos-phateor n-methyl carbamate pesticides
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